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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2S2
All Species:
34.24
Human Site:
S158
Identified Species:
57.95
UniProt:
P20042
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P20042
NP_003899.2
333
38388
S158
N
K
K
D
D
G
I
S
F
S
N
Q
T
G
P
Chimpanzee
Pan troglodytes
NP_001092026
333
38354
S158
N
K
K
D
D
G
I
S
F
S
N
Q
T
G
P
Rhesus Macaque
Macaca mulatta
XP_001105021
327
37615
S152
S
K
K
D
D
G
I
S
F
S
N
Q
T
G
P
Dog
Lupus familis
XP_534387
333
38269
S158
S
K
K
D
D
G
I
S
F
S
N
Q
T
G
P
Cat
Felis silvestris
Mouse
Mus musculus
Q99L45
331
38074
G156
E
D
S
K
K
D
D
G
I
S
F
S
S
Q
T
Rat
Rattus norvegicus
NP_955412
333
38225
S158
S
K
K
D
D
G
I
S
F
S
N
Q
T
G
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510012
334
38349
S159
N
K
K
D
D
G
I
S
F
S
N
Q
T
G
P
Chicken
Gallus gallus
NP_989928
334
38418
S159
S
K
K
D
D
G
I
S
F
S
L
Q
S
G
P
Frog
Xenopus laevis
NP_001090286
332
38131
S157
I
K
K
D
D
G
I
S
F
S
S
Q
L
G
P
Zebra Danio
Brachydanio rerio
NP_997840
327
37446
T152
S
K
N
A
D
D
I
T
F
S
T
Q
T
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P41375
312
35199
E137
D
D
K
S
E
D
K
E
N
D
E
D
N
S
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21230
250
27561
I116
G
D
K
K
K
F
A
I
K
L
P
E
V
A
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q41969
268
30644
L122
D
Y
I
Y
D
E
L
L
G
R
V
F
N
I
L
Baker's Yeast
Sacchar. cerevisiae
P09064
285
31556
L129
S
I
Q
Q
E
V
G
L
P
Y
S
E
L
L
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.9
98.1
N.A.
95.5
96.6
N.A.
96.7
94.3
87.6
77.7
N.A.
58.2
N.A.
45.3
N.A.
Protein Similarity:
100
99.6
98.1
99.4
N.A.
98.1
98.5
N.A.
98.1
96.7
92.1
87.3
N.A.
69.9
N.A.
56.7
N.A.
P-Site Identity:
100
100
93.3
93.3
N.A.
6.6
93.3
N.A.
100
80
80
60
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
13.3
100
N.A.
100
93.3
86.6
73.3
N.A.
20
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.2
39.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
54.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
8
0
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
22
0
58
72
22
8
0
0
8
0
8
0
0
0
% D
% Glu:
8
0
0
0
15
8
0
8
0
0
8
15
0
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
65
0
8
8
0
0
0
% F
% Gly:
8
0
0
0
0
58
8
8
8
0
0
0
0
65
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
8
0
0
0
65
8
8
0
0
0
0
8
0
% I
% Lys:
0
65
72
15
15
0
8
0
8
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
8
15
0
8
8
0
15
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
22
0
8
0
0
0
0
0
8
0
43
0
15
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
65
% P
% Gln:
0
0
8
8
0
0
0
0
0
0
0
65
0
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% R
% Ser:
43
0
8
8
0
0
0
58
0
72
15
8
15
8
15
% S
% Thr:
0
0
0
0
0
0
0
8
0
0
8
0
50
0
8
% T
% Val:
0
0
0
0
0
8
0
0
0
0
8
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
8
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _